Direct stimulation of T cells by type I IFN enhances the CD8+ T cell response during cross-priming.

نویسندگان

  • Agnes Le Bon
  • Vanessa Durand
  • Elisabeth Kamphuis
  • Clare Thompson
  • Silvia Bulfone-Paus
  • Cornelia Rossmann
  • Ulrich Kalinke
  • David F Tough
چکیده

Type I IFN (IFN-alphabeta), which is produced rapidly in response to infection, plays a key role in innate immunity and also acts as a stimulus for the adaptive immune response. We have investigated how IFN-alphabeta induces cross-priming, comparing CD8+ T cell responses generated against soluble protein Ags in the presence or absence of IFN-alphabeta. Injection of IFN-alpha was found to prolong the proliferation and expansion of Ag-specific CD8+ T cells, which was associated with marked up-regulation of IL-2 and IL-15 receptors on Ag-specific cells and expression of IL-15 in the draining lymph node. Surprisingly, neither IL-2 nor IL-15 was required for IFN-alpha-induced cross-priming. Conversely, expression of the IFN-alphabetaR by T cells was shown to be necessary for effective stimulation of the response by IFN-alpha. The finding that T cells represent direct targets of IFN-alphabeta-mediated stimulation reveals an additional mechanism by which the innate response to infection promotes adaptive immunity.

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عنوان ژورنال:
  • Journal of immunology

دوره 176 8  شماره 

صفحات  -

تاریخ انتشار 2006